Oleuropein alleviates myocardial ischemia-reperfusion injury by suppressing oxidative stress and excessive autophagy via TLR4/MAPK signaling pathway.
Jia HeLiting HuangKaili SunJilang LiShan HanXiang GaoQin-Qin WangShilin YangWen SunHongwei GaoPublished in: Chinese medicine (2024)
This study shows that OP binds to TLR4 to regulate oxidative stress and autophagy for protecting damaged cardiomyocytes, supporting that OP can be a potential therapeutic agent for MIRI.
Keyphrases
- oxidative stress
- ischemia reperfusion injury
- signaling pathway
- induced apoptosis
- toll like receptor
- diabetic rats
- inflammatory response
- dna damage
- pi k akt
- immune response
- endoplasmic reticulum stress
- cell death
- epithelial mesenchymal transition
- left ventricular
- nuclear factor
- heart failure
- weight gain
- physical activity
- body mass index
- high glucose