Resensitization to colistin results in rapid and stable recovery of adherence, serum resistance and ompW in Acinetobacter baumannii.
Jale BoralCansel VatanseverGulin OzcanŞiran KeskeSirin MenekseMehmet GonenFüsun CanPublished in: PloS one (2024)
In this study, we observed that A. baumannii regulates adhesion, efflux pumps and serum-resistance associated genes as an early response to colistin stress. Besides, the ompW protein disappears in the cell membrane of colistin resistant cells which recovers after resensitization to colistin. The lack of ompW protein in colistin-resistant cells should be taken into consideration for escape mutants in development of antivirulence vaccination or treatment options.
Keyphrases
- acinetobacter baumannii
- multidrug resistant
- drug resistant
- pseudomonas aeruginosa
- induced apoptosis
- klebsiella pneumoniae
- escherichia coli
- gram negative
- cell cycle arrest
- cystic fibrosis
- biofilm formation
- endoplasmic reticulum stress
- oxidative stress
- type diabetes
- amino acid
- protein protein
- insulin resistance
- stress induced
- metabolic syndrome
- weight loss
- pi k akt
- bioinformatics analysis
- glycemic control
- cell migration