PDLIM3 knockdown promotes ferroptosis in endometriosis progression via inducing Gli1 degradation and blocking Hedgehog signaling pathway.

Mingwei LiuXianxian WangJiannan Zhu

Published in: Journal of assisted reproduction and genetics (2024)

Collectively, silencing of PDLIM3 facilitates ferroptosis in EMS by inducing Gli1 degradation and blocking Hedgehog signaling. It may provide an alternative strategy for developing therapeutic agents of EMS in the future.

Keyphrases

epithelial mesenchymal transition
signaling pathway
cell death
emergency medical
pi k akt
current status
induced apoptosis
cell proliferation
oxidative stress