Pre-Exposure Prophylaxis Perspectives, Sociodemographic Characteristics, and HIV Risk Profiles of Cisgender Women Seeking and Initiating PrEP in a US Demonstration Project.
Jill BlumenthalRaphael LandovitzSonia JainFeng HeRyan KofronEric EllorinGifty M NtimJamila K StockmanKatya CoradoK Rivet AmicoDavid J MooreSheldon MorrisPublished in: AIDS patient care and STDs (2022)
Little information is known about the cisgender women who seek and initiate pre-exposure prophylaxis (PrEP) for HIV prevention in the United States. Adherence Enhancement Guided by Individualized Texting and Drug Levels was a 48-week single-arm open-label demonstration study of daily oral tenofovir disoproxil fumaratel emtricitabine (TDF/FTC) in cisgender women ≥ 18 years old at risk for HIV. Participants were surveyed at screening and enrollment about sociodemographics, HIV risk perception and behaviors, and PrEP perspectives and aggregated into three risk groups according to HIV sexual risk behavior: being in a serodiscordant partnership (SD), engaging in sex work (SW), and having partners with unknown HIV status at risk for HIV (UP). One hundred sixty-seven women presented for screening with n = 31 screen failures. Of the 162 women completing enrollment, mean age was 40 (standard deviation 11), with 41% non-Hispanic Black, 22% non-Hispanic White, and 19% Latina. Compared with those who screened ineligible, enrolled participants were more likely to have heard of PrEP, had higher HIV risk perception, and reported higher perceived PrEP efficacy. Sixty-four women (47%) were categorized as SD, 21 (15%) as SW, and 51 (38%) as UP. The SW were more likely to report higher levels of drinking and drug use ( p = 0.002) and history of intimate partner violence in the past year ( p < 0.001) compared with SD and UP. Among cisgender women enrolled, there were significant differences between the three risk groups by demographics, HIV risk behavior, and PrEP perspectives, suggesting that interventions to successfully implement PrEP in US women may need to be tailored by HIV risk group. Clinical Trial Registration number: NCT02584140.
Keyphrases
- men who have sex with men
- hiv testing
- hiv positive
- antiretroviral therapy
- hiv infected
- human immunodeficiency virus
- polycystic ovary syndrome
- hepatitis c virus
- hiv aids
- clinical trial
- breast cancer risk
- open label
- pregnancy outcomes
- mental health
- pregnant women
- cervical cancer screening
- squamous cell carcinoma
- south africa
- adipose tissue
- metabolic syndrome
- depressive symptoms
- insulin resistance
- radiation therapy
- quality improvement
- rectal cancer
- smoking cessation
- locally advanced
- weight loss
- electronic health record
- phase ii study