Colorectal cancer development is affected by the ECM molecule EMILIN-2 hinging on macrophage polarization via the TLR-4/MyD88 pathway.

Eva Andreuzzi Albina Fejza Maurizio Polano Evelina Poletto Lucrezia CamiciaGreta CarobolanteGiulia TarticchioFederico TodaroEmma Di Carlo Melania Scarpa Melania Scarpa Alice Paulitti Alessandra Capuano Vincenzo Canzonieri Stefania Maiero Mara Fornasarig Renato Cannizzaro Roberto Doliana Alfonso Colombatti Paola Spessotto Maurizio Mongiat

Published in: Journal of experimental & clinical cancer research : CR (2022)

These novel results indicate that EMILIN-2 is a key regulator of the tumor-associated inflammatory environment and may represent a promising prognostic biomarker for CRC patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
immune response
inflammatory response
prognostic factors
transcription factor
patient reported outcomes
extracellular matrix
patient reported