Variation in IL-21-secreting circulating follicular helper T cells in Kawasaki disease.

Meng XuYanfang JiangJian ZhangYan ZhengDeying LiuLishuang GuoSi-Rui Yang

Published in: BMC immunology (2018)

The present study is the first investigation that examined the distribution of circulating cTfh cell subsets in Kawasaki disease. Both cTfh cells and serum IL-21 are essential to the pathogenesis of KD. Our study provides further understanding of the immune response involved in KD and offers novel insights in the pathogenetic mechanism of this disease.

Keyphrases

immune response
induced apoptosis
dendritic cells
stem cells
cell proliferation
cell death
regulatory t cells
cell cycle arrest
bone marrow
mesenchymal stem cells
signaling pathway
oxidative stress
endoplasmic reticulum stress
toll like receptor
pi k akt