A randomized translational study on protein- and glucose metabolism in skeletal muscles evaluated by gene-ontology, following preoperative oral carbohydrate loading compared to overnight peripheral parenteral nutrition (PPN) before major cancer surgery.
Britt-Marie IresjöUlrika SmedhCecilia EngströmJan PerssonChristian MårtenssonKent LundholmPublished in: Journal of translational medicine (2024)
Conventional overnight preoperative PPN seems effective to induce and support improved muscle protein metabolism in patients aimed at major cancer surgery while preoperative oral carbohydrate loading, according to ERAS-protocols, was ineffective to improve skeletal muscle catabolism and should therefore not be recommended before major cancer surgery. Trial registration Clinical trials.gov: NCT05080816, Registered June 10th 2021- Retrospectively registered. https://clinicaltrials.gov/study/NCT05080816.
Keyphrases
- papillary thyroid
- minimally invasive
- skeletal muscle
- coronary artery bypass
- clinical trial
- squamous cell
- patients undergoing
- end stage renal disease
- chronic kidney disease
- lymph node metastasis
- type diabetes
- newly diagnosed
- genome wide
- gene expression
- coronary artery disease
- prognostic factors
- dna methylation
- metabolic syndrome
- amino acid
- transcription factor
- binding protein
- study protocol