Tanshinone I exerts cardiovascular protective effects in vivo and in vitro through inhibiting necroptosis via Akt/Nrf2 signaling pathway.

Youqiong ZhuoRenyikun YuanXinxin ChenJia HeYangling ChenChenwei ZhangKaili SunShilin YangZhenjie LiuHongwei Gao

Published in: Chinese medicine (2021)

Collectively, our findings indicated that TI exerted cardiovascular protective activities in vitro and in vivo through suppressing RIP1/RIP3/MLKL and activating Akt/Nrf2 signaling pathways, which could be developed into a cardiovascular protective agent.

Keyphrases

signaling pathway
pi k akt
induced apoptosis
epithelial mesenchymal transition
oxidative stress