Feasibility of removable balloon implant for simultaneous magnetic nanoparticle heating and HDR brachytherapy of brain tumor resection cavities.
Paul R StaufferDario B RodriguesRobert GoldsteinThinh NguyenYan YuShuying WanRichard WoodwardMichael GibbsIlya L VasilchenkoAlexey M OsintsevVoichita Bar-AdDennis B LeeperWenyin ShiKevin D JudyMark D HurwitzPublished in: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (2021)
These preclinical results demonstrate the feasibility of using a TBT balloon to deliver heat simultaneously with HDR brachytherapy to tumor bed around a brain tumor resection cavity, with significantly improved uniformity of heating over previous multi-catheter interstitial approaches. Considered along with results of previous clinical thermobrachytherapy trials, this new capability is expected to improve both survival and quality of life in patients with glioblastoma multiforme.