Time-dependent dual effect of NLRP3 inflammasome in brain ischemia.

Alejandra Palomino-AntolinPaloma Narros-FernándezVíctor Farré-AlinsJavier Sevilla-MonteroCeline Decouty-PérezAna Belen Lopez-RodriguezNuria FernándezLuis MongeAna I CasasMaría José CalzadaJavier Egea

Published in: British journal of pharmacology (2021)

These findings suggest that post-reperfusion NLRP3 inhibition may be an effective acute therapy for protecting the blood-brain barrier in cerebral ischemia with potential clinical translation.

Keyphrases

cerebral ischemia
nlrp inflammasome
subarachnoid hemorrhage
blood brain barrier
brain injury
liver failure
respiratory failure
drug induced
aortic dissection
multiple sclerosis
heart failure
intensive care unit
coronary artery disease
climate change
extracorporeal membrane oxygenation