Promotion of Myofibroblast Differentiation and Tissue Fibrosis by the Leukotriene B4 -Leukotriene B4 Receptor Axis in Systemic Sclerosis.

Minrui LiangJiaoyan LvZhixing JiangHang HeChen ChenYinluo XiongXiaoxia ZhuYu XueYiyun YuSen YangLingbiao WangWenjing LiMing GuanWeiguo WanRui HeHejian Zou

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

The LTB4 -BLT1 axis may contribute to fibrosis in SSc by directly promoting myofibroblast differentiation via the PI3K/Akt/mTOR pathway, and this appears to operate independently of autocrine secretion of TGFβ.

Keyphrases

systemic sclerosis
transforming growth factor
interstitial lung disease
epithelial mesenchymal transition
pulmonary fibrosis
signaling pathway