Prognostic significance of PD-1/PD-L1 expression in uveal melanoma: correlation with tumor-infiltrating lymphocytes and clinicopathological parameters.

Lata SinghMithalesh Kumar SinghMaria Cristina KenneyMartine J JagerMoshahid Alam RizviRachna MeelNeiwete LomiSameer BakhshiSeema SenRachna Meel

Published in: Cancer immunology, immunotherapy : CII (2020)

Our study suggests that increased infiltration with TILs promotes the aggressive behavior and suppresses the immune response of UM cells, thereby inhibiting immunotherapy.

Keyphrases

immune response
signaling pathway
induced apoptosis
cell cycle arrest
peripheral blood
dendritic cells
cell death
toll like receptor
oxidative stress
cell proliferation