Cyclophilin a signaling induces pericyte-associated blood-brain barrier disruption after subarachnoid hemorrhage.

Pengyu PanHengli ZhaoXuan ZhangQiang LiJie QuShilun ZuoFan YangGuobiao LiangJohn H ZhangXin LiuHaiyang HeHua FengYu-Jie Chen

Published in: Journal of neuroinflammation (2020)

This study demonstrated for the first time that CypA mediated the harmful effects of pericytes on BBB disruption after SAH, which potentially mediated by CD147/NF-κB/MMP9 signal, and junction protein degradation in the brain. By targeting CypA and pericytes, this study may provide new insights on the management of SAH patients.

Keyphrases

blood brain barrier
cerebral ischemia
subarachnoid hemorrhage
brain injury
end stage renal disease
ejection fraction
signaling pathway
prognostic factors
cell proliferation
resting state
white matter
peritoneal dialysis
functional connectivity
nuclear factor
binding protein
patient reported outcomes