Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression.

Emmanuelle BornLarissa LipskaiaMarielle BreauAmal HoussainiDelphine Paulette BeaulieuElizabeth MarcosRémi PierreMarcio Do CruzeiroMarine LefevreGenevieve DerumeauxDmitry V BulavinMarion Delcroix Rozenn QuarckVirinder ReenJesús Gil David BernardJean-Michel FlamanSerge AdnotShariq Abid

Published in: Circulation (2022)

Elimination of senescent P-ECs by senolytic interventions may worsen pulmonary hemodynamics. These results invite consideration of the potential impact on pulmonary vessels of strategies aimed at controlling cell senescence in various contexts.

Keyphrases

pulmonary hypertension
pulmonary artery
induced apoptosis
pulmonary arterial hypertension
cell cycle arrest
single cell
dna damage
physical activity
cell therapy
signaling pathway
cell death
stress induced
human health
risk assessment
cell proliferation
coronary artery
bone marrow