New Isatin-Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity.
Reem I Al-WabliAliyah A AlmomenMaha S AlmutairiAdam B KeetonGary A PiazzaMohamed I AttiaPublished in: Drug design, development and therapy (2020)
Herein, we revealed the antiproliferative activity and ADME predictions of the newly-synthesized compounds 5a-s and provided a detailed insight into the pharmacological profile of compound 5m. Thus, compounds 5a-s can potentially be exploited as new antiproliferative lead compounds for cancer chemotherapeutic.