Modulation of Hypoxia-Inducible Factors and Vascular Endothelial Growth Factor Expressions by Superfood Camu-Camu ( Myrciaria dubia ) Treatment in ARPE-19 and Fetal Human RPE Cells.

Ayaka NakaiDeokho LeeChiho ShodaKazuno Negishi Hiroyuki Nakashizuka Satoru Yamagami Toshihide Kurihara

Published in: Journal of ophthalmology (2023)

The camu-camu extract suppressed the activation of HIF and VEGF in RPE cells. This could assist anti-VEGF therapy in patients with abnormal ocular neovascularization.

Keyphrases

vascular endothelial growth factor
endothelial cells
induced apoptosis
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
cell death
stem cells
mesenchymal stem cells
induced pluripotent stem cells