An Overview of the Molecular Mechanisms Associated with Myocardial Ischemic Injury: State of the Art and Translational Perspectives.
Leonardo SchironeMaurizio ForteLuca D'AmbrosioValentina ValentiDaniele VecchioSonia SchiavonGiulia SpinosaGianmarco SartoVincenzo PetrozzaGiacomo FratiSebastiano SciarrettaPublished in: Cells (2022)
Cardiovascular disease is the leading cause of death in western countries. Among cardiovascular diseases, myocardial infarction represents a life-threatening condition predisposing to the development of heart failure. In recent decades, much effort has been invested in studying the molecular mechanisms underlying the development and progression of ischemia/reperfusion (I/R) injury and post-ischemic cardiac remodeling. These mechanisms include metabolic alterations, ROS overproduction, inflammation, autophagy deregulation and mitochondrial dysfunction. This review article discusses the most recent evidence regarding the molecular basis of myocardial ischemic injury and the new potential therapeutic interventions for boosting cardioprotection and attenuating cardiac remodeling.
Keyphrases
- left ventricular
- cardiovascular disease
- heart failure
- oxidative stress
- ischemia reperfusion injury
- cell death
- cardiac resynchronization therapy
- cerebral ischemia
- type diabetes
- physical activity
- dna damage
- south africa
- cardiovascular risk factors
- cardiovascular events
- atrial fibrillation
- single molecule
- acute heart failure
- subarachnoid hemorrhage