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The A'-helix of CYP11A1 remodels mitochondrial cristae.

Karen G RosalWei-Yi ChenBon-Chu Chung
Published in: Journal of biomedical science (2022)
CYP11A1 participates in the formation of tubulovesicular cristae in the mitochondria of steroidogenic cells. Its A'-helix is sufficient for the formation of tubulovesicular cristae and for protein integration into the membrane. CYP11A1 interacts with Hsp60, which is required for CYP11A1 accumulation. The accumulation of CYP11A1 leads to the reduction of MIC10 complex and changes mitochondrial structure.
Keyphrases
  • oxidative stress
  • induced apoptosis
  • cell cycle arrest
  • dna binding
  • cell death
  • binding protein
  • heat shock protein
  • heat shock
  • heat stress
  • endoplasmic reticulum stress
  • reactive oxygen species
  • pi k akt