The value of qualitative muscle MRI in the diagnostic procedures of myopathies: a biopsy-controlled study in 191 patients.
Diana Lehmann UrbanMohamed MohamedAlbert C LudolphJan KassubekAngela RosenbohmPublished in: Therapeutic advances in neurological disorders (2021)
The study provides guidance in the definition of the impact of muscle MRI in suspected myopathy: despite being an important diagnostic tool, qualitative MRI findings could not distinguish different types of neuromuscular diagnostic groups in comparison with the gold standard histopathologic diagnosis and/or genetic testing. The results suggest that neither muscle edema nor gadolinium enhancement are able to secure a diagnosis of myositis. The current results do not support qualitative MRI as aiding in the diagnostic distinction of various myopathies. Quantitative muscle MRI is, however, useful in the diagnostic procedure of a suspected neuromuscular disease, especially with regard to assessing progression of a chronic myopathy by quantification of the degree of atrophy and fatty replacement and in exploring patterns of muscle group involvements in certain genetic myopathies.
Keyphrases
- contrast enhanced
- magnetic resonance imaging
- skeletal muscle
- diffusion weighted imaging
- end stage renal disease
- systematic review
- magnetic resonance
- computed tomography
- late onset
- newly diagnosed
- chronic kidney disease
- prognostic factors
- rheumatoid arthritis
- high resolution
- genome wide
- peritoneal dialysis
- ultrasound guided
- idiopathic pulmonary fibrosis
- interstitial lung disease
- drug induced
- fine needle aspiration