Embryo Quality Conditions the Secretory Profile of Tolerogenic Dendritic Cell DC-10 During the Peri-Implantation Period.
Soledad GoriLaura FernándezElizabeth SoczewskiAna SchafirLara CastagnolaEsteban GrassoGustavo MartínezClaudia Pérez LeirósRosanna RamhorstPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2024)
Although remaining in a tolerogenic profile compatible with DC-10, DCs can differentially respond to decidual secreted factors based on embryo quality, changing their secretome. These results suggest that in the presence of arrested embryo, DCs could differentially shape the immunological microenvironment, contributing to arrested embryo clearance during the menstrual phase.