Full Diabetic Foot Ulcer Healing and Pain Relief Based on Platelet-Rich-Plasma gel Formulation Treatment and the Involved Pathways.
Krissia Caroline LemeGuilherme Martins NeriGabriel Gaspar BiscaroAndreia Afaz BulgareliNelson DuranMaria Candida Ribeiro ParisiÂngela Cristina Malheiros LuzoPublished in: The international journal of lower extremity wounds (2022)
Diabetic foot ulcer is a severe Diabetic Mellitus-associated complication. It is induced by poor glycemic control, which leads to peripheral neuropathy and vascular diseases. Platelet-rich plasma could be beneficial for healing processes due to its active biomolecules that promotes immunomodulation, angiogenesis, cell proliferation and analgesia.
Keyphrases
- platelet rich plasma
- glycemic control
- type diabetes
- cell proliferation
- wound healing
- pain management
- blood glucose
- chronic pain
- endothelial cells
- drug delivery
- weight loss
- early onset
- ultrasound guided
- vascular endothelial growth factor
- insulin resistance
- postoperative pain
- adipose tissue
- pi k akt
- skeletal muscle
- signaling pathway