Impact of complications after resection of pancreatic cancer on disease recurrence and survival, and mediation effect of adjuvant chemotherapy: nationwide, observational cohort study.
Anne Claire HenryJelle C van DongenIris W J M van GoorF Jasmijn SmitsAnne NagelhoutMarc G H BesselinkOlivier R BuschBert A BonsingKoop BosschaRonald M van DamSebastiaan FestenBas Groot KoerkampErwin van der HarstIgnace H de HinghMarion B van der KolkMike S L LiemVincent E De MeijerGijs A PatijnDaphne RoosJennifer M SchreinemakersFennie WitLois A DaamenHjalmar C van SantvoortI Quintus MolenaarCasper H J van EijckPublished in: BJS open (2023)
Major complications, including organ failure, negatively impact survival in patients after pancreatic cancer resection, largely mediated by adjuvant chemotherapy. Prevention or adequate treatment of complications and use of neoadjuvant treatment may improve oncological outcomes.