High-fat diet-induced obesity causes an inflammatory microenvironment in the kidneys of aging Long-Evans rats.

Thea LaurentiusUte RaffetsederClaudia FellnerRobert KobMahtab NourbakhshJürgen FloegeThomas BertschLeo Cornelius BollheimerTammo Ostendorf

Published in: Journal of inflammation (London, England) (2019)

Compared to CD-fed rats, HFD-fed obese LEV rats show significant damage of renal structures with aging. These subtle changes may sensitize the kidneys to the development of progressive CKD.

Keyphrases

high fat diet induced
insulin resistance
metabolic syndrome
weight loss
type diabetes
oxidative stress
adipose tissue
multiple sclerosis
high fat diet
stem cells
chronic kidney disease
high resolution
bariatric surgery
weight gain
obese patients