Gene-edited healthy donor CAR T cells show superior anti-tumour activity compared to CAR T cells derived from patients with lymphoma in an in vivo model of high-grade lymphoma.

Charlotte Elizabeth GrahamAgnieszka JozwikRuby Quartey-PapafioNikolaos IoannouAna M MeteloCarlo ScalaGlenda DicksonOrla StewartMaria Almena-CarrascoElisa PeranzoniAlan G RamsayPiers E M PattenThomas PertelFarzin FarzanehSandra DupouyAndrea G S BugginsReuben Benjamin

Published in: Leukemia (2021)

Keyphrases

high grade
diffuse large b cell lymphoma
crispr cas
low grade
genome wide
gene expression
dna methylation
transcription factor