Solid-State Dewetting of Thin Au Films for Surface Functionalization of Biomedical Implants.
Aliya SharipovaIvan ZlotverAlejandro SosnikEugen RabkinPublished in: Materials (Basel, Switzerland) (2023)
Biomaterial-centered infections of orthopedic implants remain a significant burden in the healthcare system due to sedentary lifestyles and an aging population. One approach to combat infections and improve implant osteointegration is functionalizing the implant surface with anti-infective and osteoinductive agents. In this framework, Au nanoparticles are produced on the surface of Ti-6Al-4V medical alloy by solid-state dewetting of 5 nm Au film and used as the substrate for the conjugation of a model antibiotic vancomycin via a mono-thiolated poly(ethylene glycol) linker. Produced Au nanoparticles on Ti-6Al-4V surface are equiaxed with a mean diameter 19.8 ± 7.2 nm, which is shown by high-resolution scanning electron microscopy and atomic force microscopy. The conjugation of the antibiotic vancomycin, 18.8 ± 1.3 nm-thick film, is confirmed by high resolution-scanning transmission electron microscopy and X-ray photoelectron spectroscopy. Overall, showing a link between the solid-state dewetting process and surface functionalization, we demonstrate a novel, simple, and versatile method for functionalization of implant surfaces.
Keyphrases
- solid state
- electron microscopy
- high resolution
- reduced graphene oxide
- soft tissue
- sensitive detection
- atomic force microscopy
- photodynamic therapy
- healthcare
- physical activity
- mass spectrometry
- gold nanoparticles
- single molecule
- methicillin resistant staphylococcus aureus
- staphylococcus aureus
- tandem mass spectrometry
- pseudomonas aeruginosa