Platelet Glycoprotein Ib α-Chain as a Putative Therapeutic Target for Juvenile Idiopathic Arthritis: A Mendelian Randomization Study.

Shan Luo Sarah L N Clarke Athimalaipet Vaidyanathan Ramanan Susan D Thompson Carl D LangefeldMiranda C MarionAlexei A GromCatherine Mary Schooling Tom R Gaunt Shiu Lun Ryan Au Yeung Yufang Bi

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

The role of platelets in thrombosis is well-established; however, our findings provide some novel genetic evidence that platelets may be causally implicated in the development of oligoarticular and RF-negative polyarticular JIA, and indicate that GPIbα may serve as a putative therapeutic target for these JIA subtypes.

Keyphrases

juvenile idiopathic arthritis
disease activity
pulmonary embolism
rheumatoid arthritis
genome wide
gene expression
dna methylation
copy number