Polyglutamine-Expanded Ataxin-3: A Target Engagement Marker for Spinocerebellar Ataxia Type 3 in Peripheral Blood.

Jeannette HübenerKirsten KuhlbrodtJulien PeladanJennifer FaberMagda M SantanaHolger HengelHeike JacobiKathrin ReetzHector Garcia-MorenoMafalda RaposoJudith van GaalenJon InfanteKatharina M SteinerJeroen de VriesMarcel M VerbeekPaola GiuntiLuis Pereira de AlmeidaManuela LimaBart van de WarrenburgLudger SchölsThomas KlockgetherMatthis Synofziknull nullOlaf Riess

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

The novel immunoassay is able to quantify polyQ-expanded ataxin-3 in plasma and CSF, whereas ataxin-3 levels in plasma correlate with disease severity. Longitudinal analyses demonstrated a high stability of polyQ-expanded ataxin-3 over a short period. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

peripheral blood
social media
early onset
sensitive detection
systematic review