Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation.

Rui QinChen ZhaoChen-Ji WangWei XuJian-Yuan ZhaoYan LinYi-Yuan YuanPeng-Cheng LinYao LiShi-Min ZhaoYan Huang

Published in: Journal for immunotherapy of cancer (2022)

Our results revealed the immune-activating efficacy of tryptophan, and suggested tryptophan supplemental may benefit IDO inhibitors and PD-1 blockade during anticancer treatments.

Keyphrases

signaling pathway
cell proliferation
single cell