YKL-40 changes are not detected in post-mortem brain of patients with Alzheimer's disease and frontotemporal lobar degeneration.

Yanaika S Hok-A-HinJeroen J M HoozemansWilliam T HuDorine WoutersJennifer C HowellAlberto RábanoWiesje M van der FlierYolande A L PijnenburgCharlotte E TeunissenMarta Del Campo

Published in: Alzheimer's research & therapy (2022)

Our data suggest that CSF YKL-40 changes may not reflect YKL-40 changes within AD and FTLD pathological brain areas. The YKL-40 reactivity associated with classical CAA hallmarks indicates a possible relationship between YKL-40, neuroinflammation, and vascular pathology.

Keyphrases

resting state
white matter
traumatic brain injury
functional connectivity
cognitive decline
multiple sclerosis
machine learning
inflammatory response
data analysis
cerebrospinal fluid