Gene detection of VDR BsmI locus and its approteins, genes and growthplication in rational drug use in patients with osteoporosis.
Yu HuangNan QiuYunna WangWanjun OuyangMiao LiangPublished in: Personalized medicine (2024)
Aim: This paper determines the polymorphism distribution of the VDR BsmI gene in 350 patients and provides medication recommendations for osteoporosis based on detection results. Materials & methods: Chi-square tests compared genotype and allele frequencies with other populations. Results: Genotype frequencies were 91.66 bb, 8.72 Bb and 0.21% BB, with allelic frequencies of 95.43 b and 4.57% B, adhering to Hardy-Weinberg equilibrium. These findings suggest that VDR gene polymorphisms, particularly at the BsmIlocus, play an essential role in bone health and osteoporosis treatment. Genotype-based drug selection reduced adverse reactions from 14 to two cases. Conclusion: These findings improve clinical treatment efficacy and guide rational drug use for osteoporosis patients.
Keyphrases
- bone mineral density
- end stage renal disease
- postmenopausal women
- ejection fraction
- newly diagnosed
- chronic kidney disease
- genome wide
- growth factor
- prognostic factors
- public health
- peritoneal dialysis
- mental health
- emergency department
- quantum dots
- climate change
- genome wide identification
- clinical practice
- health information
- smoking cessation
- patient reported
- soft tissue
- bioinformatics analysis
- recombinant human