Changing plasma cytokine, chemokine and growth factor profiles upon differing malaria transmission intensities.
Ruth AguilarJoseph J CampoSilvia ChicuecuePau CisteróAlba CatalàLeopoldina LuisItziar UbillosBeatriz GalatasPedro AideCaterina GuinovartGemma MoncunillCarlota DobañoPublished in: Malaria journal (2019)
The results show a different regulation of the cellular immune response in 2010 vs 2013 which could be related to a loss of immune-tolerance after a decline in MTI in 2010 and previous years, and a rapid re-establishment of tolerance as a consequence of more continuous exposure as MTI began increasing in 2012. Cellular immune mediators warrant further investigation as possible surrogates of MTI-associated host susceptibility or tolerance.