Prognostic impact of p16 and PD-L1 expression in patients with oropharyngeal squamous cell carcinoma receiving a definitive treatment.

Fumihiko SatoTakeharu OnoAkihiko KawaharaToshihiko KawaguchiHisaichiro TanakaKazuhide ShimamatsuTatsuyuki KakumaJun AkibaHirohito UmenoHirohisa Yano

Published in: Journal of clinical pathology (2019)

We demonstrated that PD-L1 expression on immune cells but not tumour cells might represent a useful prognostic biomarker in patients with OPSCC receiving a definitive treatment. We propose that a co-assessment of p16 and PD-L1 expression on immune cells would have greater prognostic potential compared with evaluation of each factor alone in patients with OPSCC.

Keyphrases

squamous cell carcinoma
induced apoptosis
locally advanced
oxidative stress
signaling pathway
climate change
cell proliferation
replacement therapy
smoking cessation