HPV and RAD51 as Prognostic Factors for Survival in Inoperable Oral and Oropharyngeal Cancer in Patients Unfit for Chemotherapy Treated with Hyperfractionated Radiotherapy.

Zuzana Zděblová ČermákováPavel HurníkDavid KonvalinkaJan ŠtembírekTereza ParačkováKamila ResováJakub CvekTomáš BlažekLukas Knybel Martin FormánekMariam GachechiladzeMarkus JoergerAlex SoltermannJozef ŠkardaOldřich MotykaJana Janoutová

Published in: Medicina (Kaunas, Lithuania) (2023)

We found no statistically significant differences but detected trends toward improvement in the survival of HPV-positive and RAD51 overexpressing patients unfit for surgical treatment or chemotherapy treated with hyperfractionated radiotherapy. The trends, however, indicate that in a larger group of patients, the effects of these two parameters would likely be statistically significant.

Keyphrases

prognostic factors
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
locally advanced
early stage
radiation therapy
high grade
patient reported outcomes
radiation induced
young adults
oxidative stress