Zebrafish heart regenerates after chemoptogenetic cardiomyocyte depletion.
Maria A MissinatoDaniel A ZuppoSimon C WatkinsMarcel P BruchezMichael TsangPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2021)
This cardiomyocyte ablation system did not appear to activate the epicardium and endocardium as is noted in other cardiac injury models. This approach represents a useful model to study specifically cardiomyocyte injury, proliferation and regeneration in the absence of whole organ activation. Moreover, this system can be adapted to ablate distinct cell populations in any organ system to study their function in regeneration.