Loss of NAT10 alleviates maternal high-fat diet-induced hepatic steatosis in male offspring of mice.
Qian-Ren ZhangJian-Bin ZhangFeng ShenRui XueRui-Xu YangTian-Yi RenJian-Gao FanPublished in: Obesity (Silver Spring, Md.) (2024)
NAT10 deletion in offspring hepatocytes ameliorates maternal HFD-induced hepatic steatosis through decreasing mRNA stability of CD36 and FATP2, highlighting NAT10 as a potential therapeutic target for pediatric MASLD.
Keyphrases
- high fat diet induced
- high fat diet
- insulin resistance
- birth weight
- adipose tissue
- pregnancy outcomes
- metabolic syndrome
- skeletal muscle
- mouse model
- high glucose
- type diabetes
- diabetic rats
- liver injury
- drug induced
- gestational age
- pregnant women
- human health
- nk cells
- body mass index
- risk assessment
- physical activity
- weight loss