Exploring the role of the WNT5A rs566926 polymorphism and its interactions in non-syndromic orofacial cleft: a multicenter study in Brazil.

Lorraynne Dos Santos Lara Ricardo Della Coletta Renato Assis Machado Lilianny Querino Rocha de Oliveira Hercílio Martelli Júnior Sílvia Regina de Almeida Reis Rafaela Scariot Luiz Evaristo Ricci Volpato

Published in: Journal of applied oral science : revista FOB (2024)

The WNT5A rs566926 polymorphism was associated with NSCL±P, particularly in individuals with NSCLO and high European ancestry. Epistatic interactions involving WNT5A rs566926 and variants in BMP4, GREM1, and FGFR1 may contribute to the risk of NSCL±P in the Brazilian population.

Keyphrases

cell proliferation
stem cells
mesenchymal stem cells
intellectual disability
copy number
gene expression
autism spectrum disorder