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Caspase-independent hepatocyte death: A result of the decrease of lysophosphatidylcholine acyltransferase 3 in non-alcoholic steatohepatitis.

Keisuke KakisakaYuji SuzukiYudai FujiwaraAkiko SuzukiJo KanazawaYasuhiro Takikawa
Published in: Journal of gastroenterology and hepatology (2018)
Depletion of LPCAT3 in a mouse model of NASH leads to caspase-independent cell death, and LPCAT3 is a potential therapeutic target in NASH.
Keyphrases
  • cell death
  • mouse model
  • liver injury
  • cell cycle arrest
  • drug induced
  • induced apoptosis
  • risk assessment
  • pi k akt