Reckless Generosity, Parkinson's Disease and Dopamine: A Case Series and Literature Review.
Deborah AmstutzJoan Philipp MichelisInes DeboveMarie Elise Maradan-GachetMartin Lenard LachenmayerJulia MuellnerKyrill SchweglerPaul KrackPublished in: Movement disorders clinical practice (2021)
Reckless generosity in PD patients with DRT might be underreported and should therefore be carefully be screened for by clinicians. A potential mechanism underlying this ICD-related behavior might be a sensitization of the mesolimbic and mesocortical dopaminergic system, leading to reduced social discounting and maladaptive reward-learning. Further research is needed to investigate the prevalence and underlying mechanisms of reckless generosity in PD patients.