α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson's disease.
Fanni F GeiblMartin T HenrichZhong XieEnrico ZampeseTatiana TkatchDavid L WokosinElena NasiriConstantin A GrotmannValina L DawsonTed M DawsonNavdeep S ChandelWolfgang Hermann OertelD James SurmeierPublished in: bioRxiv : the preprint server for biology (2023)
Taken together, our findings suggest that disruption of mitochondrial function, and the subsequent bioenergetic deficit, is a proximal step in the cascade of events induced by aSYN pathology leading to dysfunction and degeneration of neurons at-risk in PD.