Adipose stem cell crosstalk with chemo-residual breast cancer cells: implications for tumor recurrence.
Matthew A LyesSturgis PaynePaul FerrellSalvatore V PizzoScott T HollenbeckRobin E BachelderPublished in: Breast cancer research and treatment (2018)
ASCs migrate toward chemo-residual TNBC cells via SDF-1α/CXCR4 signaling, and drive chemo-residual tumor cell proliferation in a paracrine manner by secreting FGF2 and activating ERK. This paracrine signaling can potentially be targeted to prevent tumor recurrence.
Keyphrases
- cell proliferation
- stem cells
- photodynamic therapy
- cancer therapy
- signaling pathway
- breast cancer cells
- induced apoptosis
- adipose tissue
- locally advanced
- pi k akt
- squamous cell carcinoma
- cell cycle arrest
- cell cycle
- radiation therapy
- free survival
- drug delivery
- cell death
- mesenchymal stem cells
- bone marrow
- endoplasmic reticulum stress
- cell therapy