Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis.

Prakash Doddapattar Rishabh Dev Madankumar Ghatge Rakesh B Patel Manish Jain Nirav Dhanesha Steven R Lentz Anil K Chauhan

Published in: Circulation research (2022)

Genetic deletion of PKM2 in myeloid cells or limiting its nuclear translocation reduces atherosclerosis by suppressing inflammation and enhancing efferocytosis.

Keyphrases

induced apoptosis
dendritic cells
bone marrow
cardiovascular disease
acute myeloid leukemia
oxidative stress
cell cycle arrest
single cell
cell therapy
genome wide
endoplasmic reticulum stress
type diabetes
gene expression
signaling pathway
dna methylation
cell death
pi k akt