Headache: A striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution.
Edoardo CaronnaAlejandro BallvéArnau LlauradóVictor José GallardoDiana María AritonSofia LallanaSamuel López MazaMarta Olivé GadeaLaura QuibusJuan Luis RestrepoMarc Rodrigo-GisbertAndreu VilasecaManuel Hernandez GonzalezMonica Martinez GalloAlicia AlpuenteMarta Torres-FerrusRicard Pujol BorrellJosé Alvarez-SabinPatricia Pozo-RosichPublished in: Cephalalgia : an international journal of headache (2020)
Headache associated with COVID-19 is a frequent symptom, predictive of a shorter COVID-19 clinical course. Disabling headache can persist after COVID-19 resolution. Pathophysiologically, its migraine-like features may reflect an activation of the trigeminovascular system by inflammation or direct involvement of SARS-CoV-2, a hypothesis supported by concomitant anosmia.