Surgical management and outcome of newly diagnosed glioblastoma without contrast enhancement ('low grade appearance') - a report of the RANO resect group.
Philipp KarschniaJorg DietrichFrancesco BrunoAntonio DonoStephanie T JuengerNico TeskeJacob S YoungTommaso SciortinoLevin HäniMartin van den BentMichael WellerMichael A VogelbaumRamin A MorshedAlexander F HaddadAnnette M MolinaroNitin TandonJuergen BeckOliver SchnellLorenzo BelloShawn Hervey-JumperNiklas ThonStefan J GrauYoshua EsquenaziRoberta RudàSusan M ChangMitchell S BergerDaniel P CahillJoerg-Christian TonnPublished in: Neuro-oncology (2023)
The absence of contrast enhancement characterizes a less aggressive clinical phenotype of IDH-wildtype glioblastomas. Maximal resection of non-CE tumors has prognostic implications and translates into favourable outcome.