Potential adverse effects of botanical supplementation in high-fat-fed female mice.
Scott FullerYongmei YuTamra MendozaDavid M RibnickyWilliam T CefaluZ Elizabeth FloydPublished in: Biology of sex differences (2018)
Data from the current study indicates that dietary supplementation with PMI5011 and bitter melon evokes a divergent, and generally less favorable, set of metabolic responses in female mice compared to effects previously observed in males. Our findings underscore the importance of considering sex-related variations in responses to dietary supplementation aimed at combating metabolic syndrome.