The genetic and immune features of salivary gland secretory carcinoma with high-grade transformation.
Yu WangJing-Jing SunBao SunChunye ZhangZhen TianLizhen WangJiang LiPublished in: Oral diseases (2024)
Our findings reveal novel gene alterations involved in the progression of HGT in SCs. Most HGT SCs patients cannot benefit from PD-L1 blocking and may be approached with a distinct treatment strategy including the lymph node dissection and application of molecular target drugs in precision oncology.
Keyphrases
- high grade
- genome wide
- end stage renal disease
- ejection fraction
- copy number
- newly diagnosed
- chronic kidney disease
- lymph node
- peritoneal dialysis
- palliative care
- low grade
- squamous cell carcinoma
- gene expression
- dna methylation
- patient reported outcomes
- sentinel lymph node
- radiation therapy
- minimally invasive
- drug induced
- patient reported
- locally advanced