Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction.
Yu-Chen WangYen Chin KoayCalvin PanZhiqiang ZhouWai Hong Wilson TangJennifer D WilcoxXinmin S LiAlexia ZagourasFrancine Z MarquesHooman AllayeeFederico E ReyDavid M KayeJohn F O'SullivanStanley L HazenYang CaoAldons J LusisPublished in: Circulation research (2024)
Our findings reveal that IPA protects against diastolic dysfunction in HFpEF by enhancing the nicotinamide adenine dinucleotide salvage pathway, suggesting the possibility of therapeutic management by either altering the gut microbiome composition or supplementing the diet with IPA.