Natriuretic Peptide Oligomers Cause Proarrhythmic Metabolic and Electrophysiological Effects in Atrial Myocytes.
Zhenjiang YangTuerdi SubatiKyungsoo KimMatthew B MurphyOwen P DoughertyIsis L ChristopherJoseph C Van AmburgKaylen K WoodallJoey V BarnettKatherine T MurrayPublished in: Circulation. Arrhythmia and electrophysiology (2022)
These findings provide compelling evidence that natriuretic peptide oligomers are novel mediators of atrial arrhythmia susceptibility. Moreover, the accelerated oligomerization by mutANP supports a role for these mediators in the pathophysiology of this mutation in atrial fibrillation.