Renoprotective Effect of Liraglutide Is Mediated via the Inhibition of TGF-Beta 1 in an LLC-PK1 Cell Model of Diabetic Nephropathy.

Vjera NinčevićMilorad ZjalicTea Omanović KolarićMartina SmolićTomislav Kizivat Lucija Kuna RoguljicAleksandar VčevAshraf TabllInes Bilić Ćurčić

Published in: Current issues in molecular biology (2022)

The protective effect of Liraglutide is mediated through the inhibition of TGF beta, but this effect is dependent on the extent of cellular damage and the type of toxic environment. Based on the WB analysis we have revealed the signaling pathways involved in cytoprotective and cytotoxic effects of the drug itself, and further molecular studies in vitro and vivo are required to elucidate the complexity of the pathophysiological mechanisms of Liraglutide under conditions of hyperglycemia and oxidative stress.

Keyphrases

diabetic nephropathy
oxidative stress
single cell
transforming growth factor
signaling pathway
diabetic rats
dna damage
induced apoptosis
epithelial mesenchymal transition
cell therapy
ischemia reperfusion injury
mesenchymal stem cells
single molecule
electronic health record
heat stress