Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation.

Yike Zhu Matthew Ackers-Johnson Muthu K Shanmugam Leroy Sivappiragasam Pakkiri Chester Lee Drum Yanpu Chen Johnny Kim Wyatt G Paltzer Ahmed I Mahmoud Wilson Lek Wen Tan Mick Chang Jie Lee Jianming JiangDanh Anh Tuan LuuShi Ling Ng Peter Yi Qing LiAnhui WangRong Qi Gabriel Jing Xiang Ong Timothy Yu Ng Jody Jonathan Haigh Zenia Tiang Arthur Mark Richards Roger Sik Yin Foo

Published in: Circulation (2024)

/mammalian target of rapamycin complex 1 axis dependency for dedifferentiating cardiomyocytes. Further study will be needed to extrapolate and assess its relevance to other cell state transitions as well as in heart regeneration.

Keyphrases

stem cells
single cell
heart failure
cell therapy
angiotensin ii
atrial fibrillation
endothelial cells