Hawthorn leaves flavonoids attenuate cardiac remodeling induced by simulated microgravity.

Tian LiuYuqi MaHui ZhaoPengli WangYan NiuYuehuan HuXi ShenMingxia ZhangBing YanJun Yu

Published in: Pharmaceutical biology (2023)

HLF plays a protective effect on HU-induced cardiac remodelling by enhancing NPRA-cGMP-PKG pathway and suppressing the calcineurin-NFAT pathway, which provides a theoretical basis for use in clinical therapies.

Keyphrases

left ventricular
high glucose
nitric oxide
signaling pathway
diabetic rats
oxidative stress
protein kinase
heart failure
inflammatory response